Defined microenvironments trigger in vitro gastrulation in human pluripotent stem cells
P. Srivastava, S. Romanazzo, J. Ireland, S. Nemec, T. G. Molley, P. Jayathilaka, E. Pandzic, A. Yeola, V. Chandrakanthan, J. Pimanda, K. Kilian
This study shows that microconfinement of pluripotent stem cells on hydrogels triggers gastrulation-like events without exogenous factors, leading to primitive streak formation and lineage specification.
bioRxiv · Oct 28, 2021Bioengineering