Author

J. J. E. K. Harrison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

E. Arnold· 3 shared F. X. Ruiz· 3 shared J. D. Bauman· 2 shared J. J. DeStefano· 2 shared D. Lyumkis· 1 shared D. O. Passos· 1 shared J. B. Hopkins· 1 shared J. F. Bruhn· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiophysics

E. Arnold

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivMay 27, 2022

Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

R. Yadav, V. V. Courouble, S. K. Dey…·E. Arnold

The paper elucidates the structural basis and cleavage order of SARS-CoV-2 nsp7-11 polyprotein processing by Mpro, with implications for Mpro inhibition.

DOI 10.1126/sciadv.add2191

humanstructural biology

𝕏 PostBluesky

BiophysicsbioRxivPreprintOct 3, 2021

Cryo-EM Structure of the Pol Polyprotein Provides Insights into HIV Maturation

J. J. E. K. Harrison, D. O. Passos, J. F. Bruhn…·E. Arnold

The paper determines the cryo-EM structure of the HIV-1 Pol polyprotein intermediate, revealing how RT dimerization activates proteolytic processing by bringing PR monomers together.

DOI 10.1101/2021.10.03.462959

humancryo-EM

𝕏 PostBluesky

BiophysicsbioRxivNov 23, 2020

Crystal Structure of a Retroviral Polyprotein:Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

J. J. E. K. Harrison, S. Tuske, K. Das…·E. Arnold

This paper reports the crystal structure of prototype foamy virus protease-reverse transcriptase (PR-RT), revealing its monomeric architecture and domain organization compared to HIV-1 enzymes.

DOI 10.3390/v13081495

virusprotein structure

𝕏 PostBluesky