R. Yadav

Investigating Quinclorac Binding to Human Serum Albumin using Spectroscopy and Molecular Docking

This study investigates quinclorac binding to human serum albumin using spectroscopy and molecular docking, revealing high-affinity binding and identifying Sudlow site I as the primary binding site.

High-resolution fleezers reveal duplex opening and stepwise assembly by an oligomer of the DEAD-box helicase Ded1p

This study uses high-resolution optical tweezers to show Ded1p oligomers unwind RNA duplexes in 4-6 bp steps through dynamic protomer assembly and ATP hydrolysis.

Conservation of heat stress acclimation by the inositol polyphosphate multikinase, IPMK responsible for 4/6-InsP7 production in land plants

This study identifies IPMK as the enzyme responsible for producing 4/6-InsP7 in land plants and shows its role in heat stress acclimation through regulation of HSF transcription activity.

Photolipid excitation triggers depolarizing optocapacitive currents and action potentials

The paper demonstrates that photolipids can trigger optocapacitive currents and action potentials through light-induced changes in membrane capacitance and mechanosensitive channel activity.

ITPK1 regulates jasmonate-controlled root development in Arabidopsis thaliana

This study shows that ITPK1 regulates JA-dependent root development in Arabidopsis by controlling JAZ repressor protein expression, without affecting JA biosynthesis or protein levels.

Structural insights into agonist-binding and activation of the human complement C3a receptor

This study presents structural insights into C3a-C3aR interactions and identifies a G-protein-biased agonist for the receptor.

Mechanistic basis of staphylococcal interspecies competition for skin colonization

This study investigates the structural and functional basis of staphylococcal adhesion to skin and reveals cross-inhibition between S. epidermidis and S. aureus.

A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening

This study develops a diet-independent zebrafish model of NAFLD that mimics patient lipid profiles and demonstrates responsiveness to Rosiglitazone treatment.

Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology

This study uses transgenic mouse models to show that a heightened type 1 IFN response protects against SARS-CoV-2-induced immunopathology, with Irgm1 as a potential therapeutic target.

Identification of a multipotent lung progenitor for lung regeneration

The paper identifies a multipotent lung progenitor that co-expresses endothelial and epithelial markers and contributes to multi-lineage regenerative patches in a transplantation model.

Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

The paper elucidates the structural basis and cleavage order of SARS-CoV-2 nsp7-11 polyprotein processing by Mpro, with implications for Mpro inhibition.

Elongated Hypocotyl 5 (HY5) regulates BRUTUS (BTS) to maintain Iron homeostasis in Arabidopsis thaliana.

This study shows HY5 regulates Fe deficiency responses in Arabidopsis by modulating BTS and Fe uptake genes.

Predicting Protein Function and Orientation on a Gold Nanoparticle Surface Using a Residue-Based Affinity Scale

This paper develops a residue-based affinity scale to predict protein orientation on gold nanoparticles, showing it accurately predicts orientation and activity for several enzymes.

Arabidopsis PFA-DSP-type phosphohydrolases target specific inositol pyrophosphate messengers

This study identifies Arabidopsis PFA-DSP proteins as specific inositol pyrophosphate phosphohydrolases, revealing their role in regulating these signaling molecules.

Structural insight into the dual function of LbpB in mediating Neisserial pathogenesis

This study presents the structures of LbpB from Neisseria species in complex with lactoferrin, revealing its dual role in iron acquisition and immune evasion.

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics

This study uses HDX-MS and XL-MS to analyze the structural dynamics of the full-length SARS-CoV-2 nsp7:nsp8 complex, revealing conformational flexibility and a different assembly model compared to SARS-CoV.

Local auxin biosynthesis promotes shoot patterning and stem cell differentiation in Arabidopsis shoot apex

The paper shows that auxin biosynthesis by TAA1 and TAR2 in Arabidopsis SAM is essential for patterning the central and peripheral zones and differentiation of stem cells into specific cell types.

Conserved tryptophan mutation disrupts structure and function of immunoglobulin domain revealing unusual tyrosine fluorescence

This study investigates the structural and functional impact of a tryptophan mutation in palladin's Ig domain, revealing an anomalous tyrosine fluorescence due to proton transfer.

Fungal communities (Mycobiome) as potential ecological indicators within confluence stretch of Ganges and Yamuna Rivers, India

The paper analyzes fungal communities in sediment samples from the confluence of Ganges and Yamuna Rivers to assess their potential as ecological indicators of pollution and eutrophication.