Feedback in the β-catenin destruction complex imparts bistability and cellular memory
M. J. Cantoria, E. Alizadeh, J. Ravi, N. Bunnag, A. N. Kettenbach, Y. Ahmed, A. L. Paek, J. J. Tyson, K. Doubrovinski, E. Lee, C. A. Thorne
The paper shows that positive feedback in the β-catenin destruction complex creates bistability and memory in Wnt signaling, leading to switch-like cellular responses.
bioRxiv · Jan 28, 2022Cell Biology