A. N. Kettenbach

Acetylation of WCC is dispensable for the core circadianclock but differentially regulates acute light responses in Neurospora

This study shows acetylation and mono-methylation of WCC in Neurospora are not essential for circadian rhythm timing but influence light responses.

A crucial role for dynamic expression of components encoding the negative arm of the circadian clock

This study identifies brd-8 as a circadian-regulated component of the NuA4 histone acetyltransferase complex that modulates frq expression and circadian rhythm in Neurospora.

Quantitative proteomics and phosphoproteomics of PPP2R5D variants reveal deregulation of RPS6 phosphorylation through converging signaling cascades

The paper uses proteomics and phosphoproteomics to analyze PPP2R5D variants, finding RPS6 hyperphosphorylation and mTORC1 activation through different pathways in E198K and E420K variants.

Inducible protein degradation as a strategy to identify Phosphoprotein Phosphatase 6 substrates in RAS-mutant colorectal cancer cells

The paper uses inducible protein degradation to identify Phosphoprotein Phosphatase 6 substrates in RAS-mutant colorectal cancer cells and reveals its role in mitotic regulation.

Phosphoprotein Phosphatase Activity Positively Regulates Oligomeric Pyrin to Trigger Inflammasome Assembly in Phagocytes

This study identifies phosphoprotein phosphatase activity as a positive regulator of oligomeric pyrin, essential for inflammasome assembly in phagocytes.

Feedback in the β-catenin destruction complex imparts bistability and cellular memory

The paper shows that positive feedback in the β-catenin destruction complex creates bistability and memory in Wnt signaling, leading to switch-like cellular responses.

Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation

This study investigates how C-terminal methylation regulates PP2A, PP4, and PP6 holoenzyme assembly using proteomics and genetic approaches, revealing methylation-dependent interactions in cancer and non-transformed cells.

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway

This study identifies Ssn3 kinase substrates involved in hyphal growth repression through Flo8 phosphorylation in C. albicans.

PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107

This study identifies a conserved SLiM in p107 that mediates B55 recruitment and dephosphorylation, revealing a general mechanism for PP2A/B55 substrate recognition.

Selective dephosphorylation by PP2A-B55 directs the meiosis I - meiosis II transition in oocytes

The paper identifies PP2A-B55's role in meiosis I to II transition through selective dephosphorylation of threonine residues in sea star oocytes.

Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis

This study identifies Pak1 as a kinase that phosphorylates Mid1 to regulate cytokinesis in fission yeast by controlling CAR assembly and division plane positioning.

STK32A is a dual-specificity AGC kinase with a preference for acidic substrates

This study identifies STK32A as a dual-specificity AGC kinase preferring acidic substrates, revealing structural and evolutionary features supporting its substrate specificity.

A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1

This study identifies how Cdr1/Nim1 kinase inhibits Wee1 to promote mitotic entry by phosphorylating specific serine residues in yeast.

A complex containing lysine-acetylated actin inhibits the formin INF2

The paper identifies a complex of lysine-acetylated actin and CAP as an inhibitor of INF2, revealing a novel mechanism of facilitated auto-inhibition linked to disease.