Author

J. Johansen-Leete

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Organism:virus· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

C. J. Jackson· 2 shared C. Nitsche· 2 shared R. J. Payne· 2 shared S. Ullrich· 2 shared A. Aggarwal· 1 shared A. Ashhurst· 1 shared G. Otting· 1 shared J. Ton· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

C. J. Jackson

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2 papers

Recent·Most cited

Predicting antiviral resistance mutations in SARS-CoV-2 main protease with computational and experimental screening

V. M. Sasi, S. Ullrich, J. Ton, S. E. Fry, J. Johansen-Leete, R. J. Payne, C. Nitsche, C. J. Jackson

This study identifies resistance mutations in SARS-CoV-2 main protease to the drug Nirmatrelvir using computational screening and experimental validation.

Biochemistry · Nov 3, 2022Peer-reviewedBiochemistry

Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display

J. Johansen-Leete, S. Ullrich, S. Fry, R. Frkic, M. Bedding, A. Aggarwal, A. Ashhurst, K. Ekanayake, M. Mahawaththa, V. Sasi, T. Passioura, M. Larance, G. Otting, S. G. Turville, C. J. Jackson, , R. J. Payne

This study identifies cyclic peptides targeting SARS-CoV-2 main protease using mRNA display, showing antiviral activity in vitro.

bioRxiv · Aug 23, 2021Biochemistry