Structural basis for membrane attack complex inhibition by CD59
E. C. Couves, S. Gardner, T. B. Voisin, J. K. Bickel, P. J. Stansfeld, E. W. Tate, D. Bubeck
This study reveals how CD59 inhibits MAC pore formation by binding C8 and deflecting C9, using cryo-EM structures and simulations.
bioRxiv · Sep 5, 2022Immunology