J. K. Hobbs

Flap endonuclease Substrate Interactions studied using Dynamic Single-Molecule Atomic Force Microscopy

This study uses dynamic single-molecule atomic force microscopy to observe FEN-DNA interactions, revealing how FEN binds, slides, and cleaves branched DNA substrates.

The roles of GpsB and DivIVA in Staphylococcus aureus growth and division

This study investigates the roles of DivIVA and GpsB in S. aureus cell cycle and morphogenesis, finding that GpsB regulates cell shape by affecting peptidoglycan synthesis.

PBP1 of Staphylococcus aureus has multiple essential functions in cell division

This study shows PBP1 in Staphylococcus aureus has essential roles in cell division through its enzymatic activity and PASTA domains, affecting septum formation and morphology.

An Exhaustive Multiple Knockout Approach to Understanding Cell Wall Hydrolase Function in Bacillus subtilis

This paper identifies the minimal set of cell wall hydrolases required for growth in Bacillus subtilis by creating a strain lacking 40 hydrolases, showing that only two remain essential.

Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases

This study uses atomic force microscopy to measure the mechanical properties of breast cancer bone metastases and finds they are more compliant than other cancer models.

Mechanical Heterogeneity in the Bone Microenvironment as Characterised by Atomic Force Microscopy

This study uses atomic force microscopy to characterize the mechanical heterogeneity of different regions in murine bones, revealing significant variations in elastic and viscoelastic properties across age and tissue types.

Architecture and self-assembly of the Clostridium sporogenes/botulinum spore surface illustrate a general protective strategy across spore formers

The paper reveals the architecture and self-assembly of the exosporium in Clostridium sporogenes, showing a conserved protective strategy across spore-forming bacteria.