R. Hughes

IFNB induced by non-lytic virus immunotherapy promotes improved survival in hepatocellular carcinoma, mediated by MHCII-independent cytotoxic CD4+ T-cells

This paper shows that uv-inactivated reovirus combined with sorafenib improves survival in HCC by promoting IFNβ-induced cytotoxic CD4+ T-cell responses that are MHCII-independent.

Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies

This paper presents a microfluidics-based method to rapidly discover monoclonal antibodies from antigen-specific antibody secreting cells, achieving high-affinity and neutralizing antibodies against SARS-CoV-2.

Exploring the potential of using simulation games for engaging with sheep farmers about lameness recognition

This study evaluates a simulation game designed to help sheep farmers recognize lameness, finding no link between game performance and real-life experience but noting potential for future development.

Glutarate regulates T cell function and metabolism

This study shows that glutarate regulates T cell function and metabolism by inhibiting KGDDs and modifying the pyruvate dehydrogenase E2 subunit, enhancing CD8+ T cell cytotoxicity and reducing tumor growth.

Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases

This study uses atomic force microscopy to measure the mechanical properties of breast cancer bone metastases and finds they are more compliant than other cancer models.

Mechanical Heterogeneity in the Bone Microenvironment as Characterised by Atomic Force Microscopy

This study uses atomic force microscopy to characterize the mechanical heterogeneity of different regions in murine bones, revealing significant variations in elastic and viscoelastic properties across age and tissue types.

Nanoscale pattern extraction from relative positions of sparse 3D localisations

The paper introduces a method to extract high-resolution ordered features from localisation microscopy data by analyzing relative molecular positions, applied to infer ultrastructure of various biological structures.

Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

This study identifies Rv3722c as the primary aspartate aminotransferase in Mtb, revealing its role in nitrogen distribution and highlighting it as a potential drug target.

N-terminal β-strand underpins biochemical specialization of an ATG8 isoform

The paper identifies the N-terminal β-strand and a single amino acid polymorphism as key determinants of binding specificity for the ATG8 isoform in potato, shaping interactions with PexRD54 and other plant proteins.

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis

This study shows that non-canonical HIF-1 stabilization is crucial for intestinal tumorigenesis, independent of hypoxia, by affecting both epithelial and microenvironmental oncogenic processes.