PARP inhibition and pharmacological ascorbate demonstrate synergy in castration-resistant prostate cancer
N. Gordon, P. T. Gallagher, N. P. Neupane, A. C. Mandigo, J. K. McCann, E. Dylgjeri, I. Vasilevskaya, C. McNair, C. J. Paller, W. K. Kelly, K. E. Knudsen, A. A. Shafi, M. J. Schiewer
This study shows that combining PARP inhibitors with pharmacological ascorbate synergistically kills castration-resistant prostate cancer cells in vitro and in vivo.
bioRxiv · Mar 23, 2023Cancer Biology