Author

J. K. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Venclovas· 2 shared G. Bigelyte· 2 shared S. K. Dooley· 2 shared S. Paulraj· 2 shared T. Karvelis· 2 shared V. Siksnys· 2 shared Z. Hou· 2 shared A. Howe· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

C. Venclovas

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Author profile →

3 papers

Recent·Most cited

Identification and evolution of Cas9 tracrRNAs

S. K. Dooley, E. K. Baken, W. Moss, A. Howe, J. K. Young

The paper presents a bioinformatic method to identify Cas9 tracrRNAs using sequence homology and secondary structure, revealing evolutionary conservation of their structure across Cas9 lineages.

bioRxiv · Sep 2, 2020Evolutionary Biology

Biochemically diverse CRISPR-Cas9 orthologs

G. Gasiunas, J. K. Young, T. Karvelis, D. Kazlauskas, T. Urbaitis, M. Jasnauskaite, M. Grusyte, S. Paulraj, P.-H. Wang, Z. Hou, S. K. Dooley, M. Cigan, C. Alarcon, N. D. Chilcoat, G. Bigelyte, , V. Siksnys

The paper characterizes the biochemical diversity of CRISPR-Cas9 orthologs, identifying varied PAM recognition and gRNA requirements across 79 Cas9 proteins.

bioRxiv · Apr 29, 2020 · PreprintBiochemistry

PAM recognition by miniature CRISPR nucleases triggersprogrammable double-stranded DNA target cleavage

T. Karvelis, G. Bigelyte, J. K. Young, Z. Hou, R. Zedaveinyte, K. Budre, S. Paulraj, V. Djukanovic, S. Gasior, A. Silanskas, C. Venclovas, V. Siksnys

This study identifies and characterizes miniature CRISPR-Cas nucleases that cleave double-stranded DNA in a PAM-dependent manner, showing their potential for programmable genome editing.

bioRxiv · Feb 20, 2020Biochemistry