Author

A. Silanskas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

M. Zaremba· 3 shared D. Rutkauskas· 2 shared G. Sasnauskas· 2 shared A. Kopustas· 1 shared A. Leavitt· 1 shared A. Lu· 1 shared C. Avraham· 1 shared C. Venclovas· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

M. Zaremba

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TIR domains produce histidine-ADPR conjugates as immune signaling molecules in bacteria

D. Sabonis, C. Avraham, A. Lu, E. Herbst, A. Silanskas, A. Leavitt, E. Yirmiya, M. Zaremba, G. Amitai, P. J. Kranzusch, R. Sorek, G. Tamulaitiene

The paper identifies His-ADPR as a novel TIR-derived immune signaling molecule in bacteria, showing its role in phage defense and structural basis for recognition.

bioRxiv · Jan 3, 2024 · PreprintMicrobiology

Advancing Understanding of DNA-BfiI Restriction Endonuclease Cis and Trans Interactions through smFRET Technology

M. Tutkus, S. Ivanovaite, J. Paksaite, A. Kopustas, G. Karzaite, D. Rutkauskas, A. Silanskas, G. Sasnauskas, M. Zaremba, S. K. Jones

This paper develops smFRET assays to study BfiI-DNA interactions, showing longer binding durations on target sites and minimal conformational changes.

bioRxiv · Mar 31, 2023 · PreprintBiophysics

Prokaryotic Argonaute from Archaeoglobus fulgidus interacts with DNA as a homodimer

E. Golovinas, D. Rutkauskas, E. Manakova, M. Jankunec, A. Silanskas, G. Sasnauskas, M. Zaremba

This study shows that AfAgo, a prokaryotic Argonaute from Archaeoglobus fulgidus, forms a stable homodimer that interacts with two DNA molecules.

bioRxiv · May 6, 2020Biochemistry

PAM recognition by miniature CRISPR nucleases triggersprogrammable double-stranded DNA target cleavage

T. Karvelis, G. Bigelyte, J. K. Young, Z. Hou, R. Zedaveinyte, K. Budre, S. Paulraj, V. Djukanovic, S. Gasior, A. Silanskas, C. Venclovas, V. Siksnys

This study identifies and characterizes miniature CRISPR-Cas nucleases that cleave double-stranded DNA in a PAM-dependent manner, showing their potential for programmable genome editing.

bioRxiv · Feb 20, 2020Biochemistry