Cellular polarity asymmetrically functionalizes pathogen recognition receptor-mediated intrinsic immune response in human intestinal epithelium cells
M. Stanifer, S. Muenchau, K. Pervolaraki, T. Kanaya, M. Mukenhirn, D. Albrecht, C. Odendall, J. Kagan, S. Bartfeld, H. Ohno, S. Boulant
The paper shows that AP-1B-mediated polarized sorting of TLR3 leads to an asymmetric immune response in human intestinal epithelial cells to basolateral vs. apical infections.
bioRxiv · Nov 7, 2019 · PreprintImmunology