M. Mukenhirn

Tight junctions regulate lumen morphology via hydrostatic pressure and junctional tension

This study investigates how tight junctions regulate lumen morphology through hydrostatic pressure and junctional tension in MDCKII cysts.

Cellular segregation in co-cultures driven by differential adhesion and contractility on distinct time scales

This study investigates how differential adhesion and contractility drive time-dependent segregation in epithelial co-cultures, showing contractility dominates short-term sorting while adhesion determines the final state.

Critical role of type III interferon in controlling SARS-CoV-2 infection, replication and spread in primary human intestinal epithelial cells

This study shows that human intestinal epithelial cells support SARS-CoV-2 infection and replication, with type III interferon more effective than type I in controlling viral spread.

Cellular polarity asymmetrically functionalizes pathogen recognition receptor-mediated intrinsic immune response in human intestinal epithelium cells

The paper shows that AP-1B-mediated polarized sorting of TLR3 leads to an asymmetric immune response in human intestinal epithelial cells to basolateral vs. apical infections.

Focal adhesion-generated cues in extracellular matrix regulate cell migration by local induction of clathrin-coated plaques

This study identifies Eps15 and Eps15R as key regulators of clathrin-coated plaque formation, linking ECM remodeling by focal adhesions to cell migration directionality.