S. Boulant

Population context drives cell-to-cell variability in interferon response in epithelial cells

The paper shows that population context affects cell-to-cell variability in interferon response in human intestinal epithelial cells, with edge cells being more responsive than central ones.

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

This study identifies USP22 as a regulator of STING and type III IFN signaling, showing its role in SARS-CoV-2 infection and antiviral defense in human intestinal epithelial cells.

Conserved induction of distinct antiviral signalling kinetics by primate interferon lambda 4 proteins

This study shows that IFN{lambda}4 induces distinct antiviral signalling kinetics compared to IFN{lambda}1 and 3 in human hepatocyte and intestinal cells, with these effects conserved in non-human primates.

A diabetic milieu increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patients

This study shows that a diabetic environment increases SARS-CoV-2 susceptibility in kidney organoids and patients by upregulating ACE2, which is critical for viral replication.

Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection

This study identifies host cell master regulators affected by SARS-CoV-2 and develops a method to find drugs that reverse their inactivation without harming beneficial immune responses.

Clathrin-independent endocytosis of Human Papillomaviruses is facilitated by actin nucleation promoting factor WASH

This study identifies WASH as a facilitator of clathrin-independent endocytosis of HPV16, independent of retromer and SNX-BAR.

Increased sensitivity of SARS-CoV-2 to type III interferon in human intestinal epithelial cells

This study shows that type III interferons are more effective than type I interferons in reducing SARS-CoV-2 infection in human intestinal epithelial cells.

The FDA-approved drug cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication

This study shows that cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication in cell lines and organoids, reducing viral replication to levels comparable to uninfected cells.

Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera

The paper develops a semi-quantitative microscopy-based assay to detect SARS-CoV-2 specific antibodies in human sera, providing a sensitive and specific method for serological analysis.

SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity

This study identifies SPINT2 as a regulator of SARS-CoV-2 infection, showing its negative correlation with viral expression and down-regulation in COVID-19 patients and chronic disease datasets.

Host Cell Proteases Drive Early or Late SARS-CoV-2 Penetration

This study investigates how SARS-CoV-2 uses different host cell proteases for entry, showing that TMPRSS2 enables rapid entry while cathepsin L and low pH are required in its absence.

Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut

This study identifies enterocytes as the main target of SARS-CoV-2 in the gut and shows the virus suppresses interferon signaling to evade immune response.

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

This study uses in situ cryo-electron tomography to visualize SARS-CoV-2 replication compartments and virion structure, revealing RNA filament organization and vRNP packaging mechanisms.

Critical role of type III interferon in controlling SARS-CoV-2 infection, replication and spread in primary human intestinal epithelial cells

This study shows that human intestinal epithelial cells support SARS-CoV-2 infection and replication, with type III interferon more effective than type I in controlling viral spread.

Correlative cryo-structured illumination fluorescence microscopy and soft X-ray tomography elucidates reovirus intracellular release pathway

This study develops a correlative imaging platform combining cryo-SIM and SXT to study reovirus release from intracellular vesicles, revealing novel virus-induced structures.

Cellular polarity asymmetrically functionalizes pathogen recognition receptor-mediated intrinsic immune response in human intestinal epithelium cells

The paper shows that AP-1B-mediated polarized sorting of TLR3 leads to an asymmetric immune response in human intestinal epithelial cells to basolateral vs. apical infections.

Focal adhesion-generated cues in extracellular matrix regulate cell migration by local induction of clathrin-coated plaques

This study identifies Eps15 and Eps15R as key regulators of clathrin-coated plaque formation, linking ECM remodeling by focal adhesions to cell migration directionality.

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

This paper shows that type I and III interferons induce interferon stimulated genes with different kinetics, and these differences are intrinsic to the signaling pathways, not receptor abundance.