Lipooligosaccharide, Vag8, and pertussis toxin of Bordetella pertussis cooperatively cause coughing in mice
Y. Hiramatsu, K. Suzuki, T. Nishida, N. Onoda, T. Satoh, S. Akira, M. Ikawa, H. Ikeda, J. Kamei, S. Derouiche, M. Tominaga, Y. Horiguchi
The paper develops a mouse model of whooping cough and identifies that LOS, Vag8, and PTx cooperatively cause coughing by modulating TRPV1 and bradykinin levels.
bioRxiv · Dec 25, 2020 · PreprintMicrobiology