K. Suzuki

A novel VCP modulator, KUS121, attenuates atherosclerosis progression by maintaining intracellular ATP and mitigating ER stress in endothelial cells

This study shows that KUS121 reduces atherosclerosis by maintaining ATP levels and reducing ER stress in endothelial cells.

Optimization of an adeno-associated viral vector for epidermal keratinocytes in vitro and in vivo

This study optimizes an AAV vector for efficient gene delivery to epidermal keratinocytes in vitro and in vivo by engineering capsid and promoter components.

Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies

This study investigates the role of ADAP1 and ARAP1 in CD63 incorporation into multivesicular body intralumenal vesicles and shows their differential regulation of CD63 localization.

Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma

This study uses spatial transcriptomics to identify medullary niche features in thymoma and thymic hyperplasia associated with myasthenia gravis pathogenesis.

Sexually dimorphic effects of pexidartinib on nerve injury-induced neuropathic pain in mice

This study investigates sex- and androgen-dependent effects of pexidartinib on neuropathic pain in mice, showing differential suppression of mechanical allodynia in males versus females and gonadectomized males.

Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks

This study shows SART1 promotes DSB end resection in HR, cooperates with BRCA1 to counteract 53BP1/RIF1, and is required for BRCA1 recruitment to DSBs.

Soil Prokaryotic and Fungal Biome Structures Associated with Crop Disease Status across the Japan Archipelago

The paper analyzes soil microbiome structures across Japan to identify microbial species sets associated with crop disease prevalence and suggests key microbes for managing disease-suppressive agroecosystems.

Rechargeable Biomineral Induced by Sulfate Reducing Bacterium Cupidesulfovibrio sp. HK-II

This study investigates biogenic mackinawite produced by Cupidesulfovibrio sp. HK-II, showing it exhibits rechargeable properties through redox reactions and structural changes during discharge and recharge.

Artificial Intelligence Enables the Label-Free Identification of Chronic Myeloid Leukemia Cells with Mitochondrial Morphological Alterations

This study uses AI with flow cytometry to identify CML cells with mitochondrial morphological changes, enabling early diagnosis and monitoring of treatment response.

Structural Organization of the Retriever-CCC Endosomal Recycling Complex

This study determines the high-resolution structure of the Retriever-CCC endosomal recycling complex using cryo-EM and reveals how cancer mutations disrupt its function.

A pancreatic cancer mouse model with human immunity

This paper introduces a mouse model of metastatic human pancreatic cancer infiltrated by human immune cells to study tumor immune microenvironment and treatment responses.

Tumor-resident regulatory T cells in pancreatic cancer express the αvβ5 integrin as a targetable activation marker

This study identifies αvβ5 integrin as a marker for activated tumor-resident Tregs in PDAC, showing that targeting it enhances immune checkpoint therapy.

Subchronic Toxicity Assessment of Perfluoroalkyl Substances by Mixed Exposure of Nine Substances at Daily Intake Relevant Concentration

This study assesses the subchronic toxicity of a PFAS mixture in mice, finding liver morphological changes and alterations in metabolism and cancer-related gene expression.

Ketone-loading as A Novel Sports Nutrition Strategy: Chronic Ketone Supplementation Elicits Further Favorable Metabolic Changes in Keto-adapted Mice

This study shows that chronic exogenous ketone body administration in keto-adapted mice increases circulating ketone bodies and enhances gene expression related to fatty acid oxidation and energy homeostasis.

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

The paper combines gene supplementation and genome editing to treat spinal muscular atrophy in mice, showing long-term therapeutic benefits.

CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

This study enhances CAR-T cell efficacy by fusing CTLA-4 cytoplasmic tails to CARs, improving anti-tumor responses in a leukemia model.

Therapeutic immune cell engineering with an mRNA : AAV-Sleeping Beauty composite system

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis

The paper uses mass cytometry to analyze immune cell subsets in bronchoalveolar lavage fluid from patients with PCP, DI-ILD, and ICI-ILD, revealing distinct immunophenotypes associated with each condition.

Facilitative interaction networks in experimental microbial community dynamics

The paper analyzes facilitative interactions in microbial communities using metagenomic data and metabolic modeling to identify feedback loops and keystone species.

Metagenomic analysis of ecological niche overlap and community collapse in microbiome dynamics

The paper uses metagenomic analysis to study how genetic resource-use profiles influence community collapse in microbiomes over time.

Mass cytometry identifies characteristic immune cell subsets in bronchoalveolar lavage fluid from interstitial lung diseases

The paper uses mass cytometry to identify distinct immune cell subsets in BALF from ILD patients, revealing disease-specific immune signatures.

Polyvalent mRNA vaccination elicited potent immune response to monkeypox surface antigens

This study develops a polyvalent mRNA vaccine against monkeypox virus and shows it elicits strong antibody responses to key surface antigens in animal models.

Alternative stable states, nonlinear behavior, and predictability of microbiome dynamics

This study shows that abrupt microbiome changes can be predicted using ecological concepts and stability indices in complex microbial communities.

Basins of attraction of microbiome structure and soil ecosystem functions

The paper investigates basins of attraction in soil microbiome structure and their associations with ecosystem functions and crop disease prevalence.

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.

Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction

This paper demonstrates the in vitro induction of hair follicles by reprogramming three-dimensional microenvironments through controlled epithelial-mesenchymal interactions, resulting in the formation of hair follicloids with functional hair shafts.

β-cell responses to high fat feeding: A role and mechanism for redox sensing by SENP1

This study identifies SENP1's role in β-cell redox sensing during high-fat feeding, showing its requirement for enhanced exocytosis and glucose intolerance.

Potent and specific human monoclonal antibodies against SARS-CoV-2 Omicron variant by rapid mRNA immunization of humanized mice

This study develops RAMIHM, a method to generate potent human monoclonal antibodies against SARS-CoV-2 Omicron using mRNA immunization of humanized mice, identifying three highly effective antibodies.

Decomposing predictability to identify dominant causal drivers in complex ecosystems

This paper introduces EcohNet, a machine learning framework for causal inference in complex ecosystems, showing it improves interaction network inference and forecasting of ecosystem components.