Application of mechanistic multiparameter optimization and large scale in vitro to in vivo pharmacokinetics correlations to small molecule therapeutic projects
F. Broccatelli, V. Veeravalli, D. Cashion, J. L. Baylon, F. Lombardo, L. Jia
This paper applies mechanistic multiparameter optimization to drug discovery, showing it can prioritize compounds effectively for clinical trials with high accuracy.
bioRxiv · Mar 6, 2024 · PreprintPharmacology & Toxicology