Z. Xie

Biodiversity in mountain soils above the treeline

This paper synthesizes research on biodiversity in mountain soils above the treeline, highlighting gaps in geographic and taxonomic coverage and the need for improved data to support conservation efforts.

PbrSYP71 regulates pollen tube growth by maintaining uneven distribution of the ER in Pyrus

This study identifies PbrSYP71 as a pollen tube-specific syntaxin that maintains uneven ER distribution by tethering ER to F-actin, promoting pollen tube growth in pear.

Microbial aromatic amino acid metabolism is modifiable in fermented food matrices to promote bioactivity

This study identifies aryl-lactates as bioactive metabolites in fermented foods and shows their production can be enhanced to boost AhR receptor activity.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

Multi-modal microvascular cerebral blood flow velocity mapping with 14T single-vessel MRI and optical microscopy in the mouse brain

This study combines 14T single-vessel MRI and optical microscopy to map cerebral blood flow velocity in mouse brain microvessels, validating measurements across modalities.

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

Vacuolar H+-ATPase Determines Daughter Cell Fates through Asymmetric Segregation of the Nucleosome Remodeling and Deacetylase Complex

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

HSP90 inhibitor NVP-HSP990 alleviates rotavirus infection

This study shows that NVP-HSP990, a HSP90 inhibitor, effectively reduces rotavirus infection in vitro and in mice by inhibiting replication and alleviating intestinal damage.

Dynamic 1D Search and Processive Nucleosome Translocations by RSC and ISW2 Chromatin Remodelers

This study investigates the dynamic search and processive nucleosome translocation mechanisms of RSC and ISW2 chromatin remodelers using optical tweezers and single-particle imaging.

Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice

This study shows that increased myeloid-derived suppressor cells (MDSCs) in mice with renal injury or aging worsen lung inflammation caused by viral pneumonia.

HDAC1-3 inhibition reduces CCR2 expression and immunosuppressive function of myeloid-derived suppressor cells

This study shows HDAC1-3 inhibitors reduce CCR2 expression and immunosuppressive function of MDSCs, enhancing antitumor effects in HCC.

Reciprocal polarization imaging of complex media.

This paper introduces reciprocal polarization imaging to quantify anisotropic properties of complex media using backscattering Mueller matrices, demonstrating its effectiveness in various applications.

Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

The effect of colonic pH on microbial activity and metabolite production using common prebiotics as substrates: an in vitro study

This study examines how colonic pH affects gut microbial composition and metabolite production using prebiotics in an in vitro setup, finding that higher pH promotes SCFA production.

CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment

This paper develops and tests a CD46-targeted alpha radioimmunotherapy, 212Pb-TCMC-YS5, showing potent tumor growth inhibition and survival improvement in multiple prostate cancer models.

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation

This paper identifies XEN602, a potent, gut-restricted DMT1 inhibitor, showing efficacy in reducing iron overload in rats and pigs with minimal systemic exposure.

Biochemical characterization of a Mycobacterium tuberculosis prolyl dipeptidyl peptidase that displays a remarkable thermostability

This study characterizes a Mycobacterium tuberculosis dipeptidyl peptidase with high thermal stability and shows its potential role in immune modulation.

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

The paper shows restoring PITPNA in T2D human islets reverses beta-cell dysfunction by improving insulin granule maturation and glucose-stimulated insulin secretion.

Single-Cell RNA-seq of Heart Reveals Intercellular Communication Drivers of Myocardial Fibrosis in Diabetic Mice

This study uses single-cell RNA-seq to identify intercellular communication drivers of myocardial fibrosis in diabetic mice, highlighting key ligand-receptor interactions and fibroblast subpopulations involved in fibrosis.

PvC3H29 interacts with and inhibits DNA binding of PvNAPs to finetune leaf senescence in switchgrass (Panicum virgatum)

PvC3H29 interacts with PvNAP1&2 to inhibit their transactivation on chlorophyll catabolism and leaf senescence in switchgrass.

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

Automated identification of chicken distress vocalisations using deep learning models

This paper develops a lightweight deep learning model to automatically identify chicken distress calls, achieving high accuracy with reduced computational requirements.

Mechanically induced nuclear shuttling of β-catenin requires co-transfer of actin

This study shows dynamic mechanical strain induces nuclear translocation of β-catenin via actin transport, while static strain promotes YAP1 nuclear entry, highlighting distinct mechanoresponses.

JAK-STAT Signaling Enables Lineage Plasticity-driven AR Targeted Therapy Resistance

The paper identifies JAK-STAT signaling as a key driver of lineage plasticity-driven resistance to AR targeted therapy in prostate cancer using integrated transcriptomic and scRNA-Seq analysis.

Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

Identification of a MarR subfamily that regulates arsenic resistance genes

This study identifies a novel MarR subfamily, MarRars, that regulates arsenic resistance genes by responding to As(III) and Sb(III) and repressing arsV expression.

Revealing the full biosphere structure and versatile metabolic functions in the deepest ocean sediment of the Challenger Deep

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.

Decoding regulatory specificity of human ribosomal proteins

This study shows that ribosomal protein (RP) deficiency affects gene expression through translational and transcriptional changes, with distinct impacts on cell growth, apoptosis, and development.

Methyltransferase SMYD5 Exaggerates IBD by Downregulating Mitochondrial Functions via Post-translational Control of PGC-1α Stability

This study identifies SMYD5 as a driver of IBD by downregulating mitochondrial functions through methylation-dependent degradation of PGC-1α in intestinal epithelial cells.

Cerebrospinal fluids from healthy pregnant women does not harbor a detectable microbial community

This study analyzes cerebrospinal fluid from healthy pregnant women and finds no evidence of a detectable microbial community after accounting for contamination.