L. Jia

Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

This study evaluates cipargamin's efficacy against Babesia species and identifies resistance mechanisms, showing its effectiveness as an anti-babesial drug but limitations due to resistance, with combination therapy with tafenoquine offering potential.

Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.

Single particle cryo-electron microscopy with an enhanced 200 kV cryo-TEM configuration achieves near-atomic resolution

This study shows that a 200 kV cryo-TEM with advanced detectors can achieve near-atomic resolution for single particle cryo-EM, comparable to 300 kV systems.

Type I interferon induces TCR-dependent and -independent antimicrobial responses in γδ intraepithelial lymphocytes

This study shows type I interferon induces antimicrobial responses in γδ IELs both independently and dependently on TCR signaling.

Application of mechanistic multiparameter optimization and large scale in vitro to in vivo pharmacokinetics correlations to small molecule therapeutic projects

This paper applies mechanistic multiparameter optimization to drug discovery, showing it can prioritize compounds effectively for clinical trials with high accuracy.

Determination and characterization of papillomaviurs and parvovirus causing mass mortality of Chinese tongue sole (Cynoglossus semilaevis) in China

This study identifies two novel viruses, CsPaV and CsPV, as the causative agents of mass mortality in farmed Chinese tongue sole, revealing their co-infection and potential for further research on viral interactions.

Revealing Molecular Mechanisms of Early-Onset Tongue Cancer by Spatial Transcriptomics

This study identifies distinct spatial transcriptomic features and molecular mechanisms in early-onset tongue cancer compared to older patients.

A syntelog-based pan-genome provides insights into rice domestication and de-domestication

This paper constructs a syntelog-based pan-genome of rice using long-read sequencing to study domestication and de-domestication, identifying introgression events and domestication genes.

Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation

The paper identifies start codon-associated ribosomal frameshifting (SCARF) as a mechanism for nutrient stress adaptation, revealing its role in amino acid recycling and selective mRNA translation.

A pilot study of stable isotope fractionation in Bombyx mori rearing

This study measures stable isotope fractionation in Bombyx mori strains across life stages to trace isotope movement and understand fractionation patterns.

A Deep Learning Approach for Histology-Based Nuclei Segmentation and Tumor Microenvironment Characterization

This study introduces HD-Yolo, a deep learning method for faster and more accurate nuclei segmentation and tumor microenvironment quantification in whole-slide images.

A unified classification system for HIV-1 5' long terminal repeats

This paper establishes a unified classification system for HIV-1 5' LTRs using public database sequences, revealing recombination events that alter transcription factor binding sites in 6 out of 22 tested strains.

Global mosquito virome profiling and mosquito spatial diffusion pathways revealed by marker-viruses

The paper profiles global mosquito viromes across species, locations, and climates, identifies core-viruses, and links viral diversity to ecological factors and mosquito movement.

Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen

This study identifies HscA as an effector protein from Aspergillus fumigatus that redirects phagosomes to the recycling expulsion pathway by anchoring p11, affecting susceptibility to invasive pulmonary aspergillosis.

Integrated molecular analysis reveals two distinct subtypes of pure seminoma of the testis

This study identifies two distinct subtypes of pure seminoma using transcriptomic analysis of The Cancer Genome Atlas data, revealing molecular differences linked to treatment response and clinical outcomes.

CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer

This study uses CRISPR screens to identify genetic factors affecting PARP inhibitor sensitivity and resistance in prostate cancer, revealing novel targets and mechanisms.

Omicron booster in ancestral strain vaccinated mice augments protective immunities against both the Delta and Omicron variants

This study shows that an Omicron-matched DNA vaccine booster enhances cross-reactive immunity against Delta and Omicron variants in mice compared to an ancestral strain booster.

Identification and characterization of the HERV-K (HML-8) group of human endogenous retroviruses in the genome

This study characterizes the HERV-K (HML-8) group in the human genome, identifying 40 proviruses and 5 solo LTR elements and determining their integration time and genomic distribution.

RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer

The paper shows that loss of RNASEH2B makes prostate cancer cells sensitive to PARP inhibitors, but co-deletion with RB1 reduces this sensitivity through BRCA2 upregulation, and ATR inhibition can restore sensitivity.

A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection.

This study identifies a γδ IEL hyperproliferative phenotype influenced by the intestinal microbiota, which enhances protection against bacterial infection.

Neuropilin-1 Mediates SARS-CoV-2 Infection in Bone Marrow-derived Macrophages

This study shows SARS-CoV-2 infects bone marrow-derived macrophages via neuropilin-1, not ACE2, and affects osteoclast function.

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

This study shows that CISH knockout in TIL enhances neoantigen reactivity and synergizes with PD1 blockade to improve tumor regression.

Electronic blood vessel

This paper develops an electronic blood vessel using flexible bio-degradable circuitry to enhance endothelization and enable gene delivery, showing good biocompatibility and patency in a rabbit model.

Decoding mRNA translatability and stability from 5'UTR

The paper uses synthetic mRNA libraries to study 5'UTR sequence elements affecting mRNA translatability and stability in mammalian cells, identifying regulatory features and decay pathways.

LonP1 Orchestrates UPRmt and UPRER and Mitochondrial Dynamics to Regulate Heart Function

This study shows LonP1 regulates UPRmt and UPRER, and mitochondrial dynamics in cardiomyocytes, impacting heart function and revealing potential therapeutic targets for heart failure.