BiophysicsbioRxiv
Metal bridge in S4 segment supports helix transition in Shaker channel
C. A. Z. Bassetto, J. L. Carvalho-de-Souza, F. Bezanilla
The paper investigates the role of metal bridges in stabilizing helical conformations of the S4 segment in Shaker channels during activation, showing slowed currents and voltage shifts with Zn2+.
DOI 10.1016/j.bpj.2019.08.035