Toll Like Receptor 9 Pathway Mediates Schlafen+-MDSC Polarization During Helicobacter-Induced Gastric Metaplasias
L. L. Ding, J. L. Chakrabarti, S. Sheriff, Q. Li, H. N. Thi Hong, R. A. Sontz, Z. E. Mendoza, A. Schreibeis, M. A. Helmrath, Y. Zavros, J. L. Merchant
This study shows that TLR9 mediates SLFN+-MDSC polarization during Helicobacter-induced gastric metaplasia, with the TLR9 C allele linked to increased risk of neoplastic complications.
bioRxiv · Jan 25, 2022Cancer Biology