Author

M. A. Helmrath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. L. Matthis· 1 shared A. S. Conchola· 1 shared A. Schreibeis· 1 shared A. Singh· 1 shared A. Vallie· 1 shared A. Wu· 1 shared C. J. Childs· 1 shared C. Loebel· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperPhysiology

A. L. Matthis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature

C. J. Childs, H. M. Poling, K. Chen, Y.-H. Tsai, A. Wu, C. W. Sweet, A. Vallie, M. K. Eiken, S. Huang, R. Schreiner, Z. Xiao, A. S. Conchola, M. F. Anderman, E. M. Holloway, A. Singh, , J. R. Spence

This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.

bioRxiv · Nov 6, 2023 · PreprintBioengineering

Toll Like Receptor 9 Pathway Mediates Schlafen+-MDSC Polarization During Helicobacter-Induced Gastric Metaplasias

L. L. Ding, J. L. Chakrabarti, S. Sheriff, Q. Li, H. N. Thi Hong, R. A. Sontz, Z. E. Mendoza, A. Schreibeis, M. A. Helmrath, Y. Zavros, J. L. Merchant

This study shows that TLR9 mediates SLFN+-MDSC polarization during Helicobacter-induced gastric metaplasia, with the TLR9 C allele linked to increased risk of neoplastic complications.

bioRxiv · Jan 25, 2022Cancer Biology

Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport

H. A. McCauley, A. L. Matthis, J. R. Enriquez, J. Nichol, J. G. Sanchez, W. J. Stone, N. Sundaram, M. A. Helmrath, M. H. Montrose, E. Aihara, J. M. Wells

This study identifies peptide YY as a regulator of ion-coupled nutrient absorption in the small intestine, showing its therapeutic potential for malabsorption.

bioRxiv · Apr 21, 2020Physiology