J. L. Merchant

Spatial profiling of neuro-immune interactions in gastroenteropancreatic NETs

This study uses spatial protein profiling to identify tissue-specific neuro-immune signatures in GEP-NETs, showing that duodenal gastrinomas express immune and pro-inflammatory factors that influence neuroendocrine traits.

Combined multiphoton microscopy and somatostatin receptor type 2 imaging of pancreatic neuroendocrine tumors

This study combines somatostatin receptor imaging and multiphoton microscopy to improve the localization of pancreatic neuroendocrine tumors.

Clinically defined mutations in MEN1 alter its tumor-suppressive function through increased menin turnover

This study shows that specific MEN1 mutations destabilize menin, reducing its tumor-suppressive function and leading to neuroendocrine tumor development.

Design, fabrication, and preclinical testing of a miniaturized, multispectral, chip-on-tip, imaging probe for intraluminal fluorescence imaging of the gastrointestinal tract

This paper designs and tests a miniaturized fluorescence imaging probe for detecting gastrointestinal tumors using exogenous contrast agents.

Quantitative Characterization of Duodenal Gastrinoma Autofluorescence Using Multi-Photon Microscopy

This study uses multiphoton microscopy to distinguish duodenal gastrinomas from normal tissue using autofluorescence and SHG signals, achieving high classification accuracy.

Menin-MLL Inhibitor MI-503 Blocks Menin Nuclear Export and Suppresses Hypergastrinemia

This study shows that MI-503 inhibits gastrin gene expression by blocking Menin nuclear export in gastrinomas.

GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming

This study shows that inactivating Men1 in glial cells leads to neuroendocrine differentiation and tumorigenesis, exploiting glial plasticity.

Toll Like Receptor 9 Pathway Mediates Schlafen+-MDSC Polarization During Helicobacter-Induced Gastric Metaplasias

This study shows that TLR9 mediates SLFN+-MDSC polarization during Helicobacter-induced gastric metaplasia, with the TLR9 C allele linked to increased risk of neoplastic complications.