J. L. Dynes

T Cell Calcium Dynamics Visualized in a Ratiometric tdTomato-GCaMP6f Transgenic Reporter Mouse

The paper develops a transgenic Ca2+ reporter mouse to visualize T cell calcium dynamics in vivo and demonstrates localized Ca2+ signaling during migration and receptor engagement.

Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility

This study shows that Orai1-mediated Ca2+ signals regulate basal T cell motility by reducing pauses during migration, enhancing cell velocity in confined spaces.