Author

I. Parker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Assay:electrophysiology· 3 Organism:human· 3 Assay:imaging· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Demuro· 2 shared A. Jairaman· 2 shared G. Ullah· 2 shared J. L. Dynes· 2 shared J. L. Nourse· 2 shared J. R. Holt· 2 shared M. M. Pathak· 2 shared S. Othy· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

A. Demuro

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology

G. A. Bertaccini, I. Casanellas, E. L. Evans, J. L. Nourse, G. D. Dickinson, G. Liu, S. Seal, A. T. Ly, J. R. Holt, T. D. Wijerathne, S. Yan, E. E. Hui, J. J. Lacroix, M. M. Panicker, S. Upadhyayula, , M. M. Pathak

This study uses HaloTag technology to visualize PIEZO1 localization and activity in hiPSC-derived cells and organoids, enabling mechanotransduction studies with high temporal resolution.

bioRxiv · Dec 22, 2023Biophysics

Intracellular injection of brain extracts from Alzheimer's disease patients trigger unregulated Ca2+ release from intracellular stores that hinders cellular bioenergetics

A. Pensalfini, A. R. Umar, C. G. Glabe, I. Parker, G. Ullah, A. Demuro

The paper shows that brain extracts from Alzheimer's patients trigger unregulated Ca2+ release from intracellular stores, disrupting bioenergetics and supporting a role for amyloid oligomers in neuronal toxicity.

bioRxiv · Apr 29, 2022Cell Biology

Aβ42 and Aβ40 oligomers form transient and persistent pores with different time evolutions and toxicities

S. I. Shah, I. Parker, G. Ullah, A. Demuro

This study shows Aβ42 and Aβ40 oligomers form different Ca2+ permeable pores with distinct time-dependent toxicities in Alzheimer's disease.

bioRxiv · Apr 29, 2022 · PreprintCell Biology

Myosin-II mediated traction forces evoke localized Piezo1 Ca2+ flickers

K. Ellefsen, J. R. Holt, A. Chang, J. L. Nourse, J. Arulmoli, A. Mekhdjian, H. Abuwarda, F. Tombola, L. A. Flanagan, A. R. Dunn, I. Parker, M. M. Pathak

The paper shows that Myosin-II mediated traction forces cause localized Piezo1 Ca2+ flickers in cells without external forces.

bioRxiv · May 13, 2019Biophysics

T Cell Calcium Dynamics Visualized in a Ratiometric tdTomato-GCaMP6f Transgenic Reporter Mouse

T. X. Dong, S. Othy, A. Jairaman, J. Skupsky, A. Zavala, I. Parker, J. L. Dynes, M. D. Cahalan

The paper develops a transgenic Ca2+ reporter mouse to visualize T cell calcium dynamics in vivo and demonstrates localized Ca2+ signaling during migration and receptor engagement.

bioRxiv · Oct 18, 2017Cell Biology

Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility

T. X. Dong, S. Othy, M. L. Greenberg, A. Jairaman, C. Akunwafo, S. Leverrier, Y. Yu, I. Parker, J. L. Dynes, Michael D. Cahalan

This study shows that Orai1-mediated Ca2+ signals regulate basal T cell motility by reducing pauses during migration, enhancing cell velocity in confined spaces.

bioRxiv · Apr 19, 2017Immunology