Interplay of macromolecular interactions during assembly of human DNA polymerase δ holoenzymes and initiation of DNA synthesis
J. L. Norris, L. O. Rogers, K. G. Pytko, R. L. Dannenberg, S. Perreault, V. Kaushik, S. Kuppa, E. Antony, M. Hedglin
This study uses FRET assays to show how RPA interactions at P/T junctions facilitate Pol δ holoenzyme assembly and DNA synthesis efficiency.
bioRxiv · May 9, 2023 · PreprintBiochemistry