Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism
C. Gaubitz, X. Liu, J. Magrino, N. P. Stone, J. Landeck, M. Hedglin, B. A. Kelch
This paper reports the cryo-EM structure of human RFC bound to PCNA, revealing an autoinhibited conformation and a novel regulatory mechanism for AAA+ ATPases.
bioRxiv · Feb 18, 2020Biochemistry