Author

N. P. Stone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:protein structure prediction· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. A. Kelch· 5 shared B. J. Hilbert· 3 shared C. Gaubitz· 3 shared J. A. Hayes· 3 shared X. Liu· 2 shared D. Hidalgo· 1 shared G. Demo· 1 shared J. Landeck· 1 shared

Activity by Year

2016-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersBiochemistry

B. A. Kelch

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

C. Gaubitz, X. Liu, J. Pajak, N. P. Stone, J. A. Hayes, G. Demo, B. A. Kelch

The paper presents cryo-EM structures of the yeast clamp loader RFC bound to PCNA, revealing the mechanism of clamp opening and DNA binding without ATP hydrolysis.

bioRxiv · Sep 23, 2021Biochemistry

Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism

C. Gaubitz, X. Liu, J. Magrino, N. P. Stone, J. Landeck, M. Hedglin, B. A. Kelch

This paper reports the cryo-EM structure of human RFC bound to PCNA, revealing an autoinhibited conformation and a novel regulatory mechanism for AAA+ ATPases.

bioRxiv · Feb 18, 2020Biochemistry

A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry

J. A. Hayes, B. J. Hilbert, C. Gaubitz, N. P. Stone, B. A. Kelch

This paper identifies and characterizes the TerS protein of bacteriophage P74-26, revealing its unique structural features and functional roles in DNA binding and TerL interaction.

bioRxiv · Nov 21, 2019Biochemistry

A hyperthermophilic phage decoration protein suggests common evolutionary origin with Herpesvirus Triplex proteins and an anti-CRISPR protein

N. P. Stone, B. J. Hilbert, D. Hidalgo, K. T. Halloran, B. A. Kelch

The paper investigates the structure and stability of a capsid protein from a hyperthermophilic phage, revealing its evolutionary relationship with herpesvirus triplex proteins and an anti-CRISPR protein.

bioRxiv · Nov 13, 2017Biochemistry

The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain

B. J. Hilbert, J. A. Hayes, N. P. Stone, R.-G. Xu, B. A. Kelch

This study investigates how the large terminase protein binds and cleaves DNA during viral genome packaging, revealing the ATPase domain's role in DNA binding and the nuclease domain's role in cleavage.

bioRxiv · Oct 19, 2016Biochemistry