C. Gaubitz

A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA

This paper identifies a second DNA binding site in yeast RFC that facilitates clamp loading at nicked or gapped DNA, enhancing DNA repair processes.

Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

The paper presents cryo-EM structures of the yeast clamp loader RFC bound to PCNA, revealing the mechanism of clamp opening and DNA binding without ATP hydrolysis.

CaMKII binds both substrates and activators at the active site

This study challenges a longstanding model of CaMKII activation by showing that activators and substrates bind to a single site rather than distinct S- and T-sites.

Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism

This paper reports the cryo-EM structure of human RFC bound to PCNA, revealing an autoinhibited conformation and a novel regulatory mechanism for AAA+ ATPases.

A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry

This paper identifies and characterizes the TerS protein of bacteriophage P74-26, revealing its unique structural features and functional roles in DNA binding and TerL interaction.