Author

J. Lascano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

B. Mehrad· 2 shared M. Brantly· 2 shared N. Khodayari· 2 shared R. Oshins· 2 shared x. qiang· 2 shared C. Eagan· 1 shared G. Wiesemann· 1 shared J. West· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCell Biology

B. Mehrad

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2 papers

Recent·Most cited

Correlation of Alpha-1 Antitrypsin Levels and Exosome Associated Neutrophil Elastase Endothelial Injury in Subjects with SARS-CoV2 Infection

J. Lascano, R. Oshins, C. Eagan, Z. Wadood, x. qiang, T. Flagg, Y. Scindia, B. Mehrad, M. Brantly, N. Khodayari

The paper investigates the correlation between exosome-associated neutrophil elastase (NE) and alpha-1 antitrypsin levels in SARS-CoV-2 patients, finding that exosome-associated NE is resistant to alpha-1 antitrypsin inhibition and correlates with endothelial injury.

bioRxiv · Jul 7, 2022Cell Biology

Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency

N. Khodayari, R. Oshins, B. Mehrad, J. Lascano, x. qiang, J. West, S. Holliday, G. Wiesemann, S. Eydgahi, M. Brantly

This study shows that cigarette smoke-exposed airway epithelial cell-derived EVs enhance pro-inflammatory activation of AATD macrophages, increasing cytokine production and neutrophil chemoattractant release.

bioRxiv · Jul 7, 2022Cell Biology