Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency
N. Khodayari, R. Oshins, B. Mehrad, J. Lascano, x. qiang, J. West, S. Holliday, G. Wiesemann, S. Eydgahi, M. Brantly
This study shows that cigarette smoke-exposed airway epithelial cell-derived EVs enhance pro-inflammatory activation of AATD macrophages, increasing cytokine production and neutrophil chemoattractant release.
bioRxiv · Jul 7, 2022Cell Biology