Author

B. Mehrad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Y. Scindia· 3 shared C. Atkinson· 2 shared J. Lascano· 2 shared M. Brantly· 2 shared N. Khodayari· 2 shared R. Oshins· 2 shared x. qiang· 2 shared A. A. Alli· 1 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

Y. Scindia

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Correlation of Alpha-1 Antitrypsin Levels and Exosome Associated Neutrophil Elastase Endothelial Injury in Subjects with SARS-CoV2 Infection

J. Lascano, R. Oshins, C. Eagan, Z. Wadood, x. qiang, T. Flagg, Y. Scindia, B. Mehrad, M. Brantly, N. Khodayari

The paper investigates the correlation between exosome-associated neutrophil elastase (NE) and alpha-1 antitrypsin levels in SARS-CoV-2 patients, finding that exosome-associated NE is resistant to alpha-1 antitrypsin inhibition and correlates with endothelial injury.

bioRxiv · Jul 7, 2022Cell Biology

Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency

N. Khodayari, R. Oshins, B. Mehrad, J. Lascano, x. qiang, J. West, S. Holliday, G. Wiesemann, S. Eydgahi, M. Brantly

This study shows that cigarette smoke-exposed airway epithelial cell-derived EVs enhance pro-inflammatory activation of AATD macrophages, increasing cytokine production and neutrophil chemoattractant release.

bioRxiv · Jul 7, 2022Cell Biology

Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis

A. A. Alli, D. Desai, A. Elshika, L. Morel, M. Conrad, B. Proneth, W. Clapp, C. Atkinson, M. Segal, L. Searcy, N. Denslow, S. Bolisetty, B. Mehrad, Y. Scindia

This study shows ferroptosis occurs in kidney tubules of lupus nephritis patients and mice, and a drug can reduce it, suggesting new treatment options.

bioRxiv · May 26, 2022Immunology

Computational modeling of macrophage iron sequestration during host defense against Aspergillus

B. Adhikari, Y. Scindia, L. Sordo Vieira, H. de Assis Lopes Ribeiro, J. Masison, N. Yang, L. Fonseca, M. Wheeler, A. Knapp, Y. Mei, B. Helba, C. Atkinson, W. Schroeder, B. Mehrad, R. Laubenbacher

The paper develops a computational model of macrophage iron sequestration during Aspergillus infection, showing that transferrin receptor-1 upregulation precedes inflammatory cytokine induction.

bioRxiv · Jan 24, 2022Immunology

In vitro infection of human lung tissue with SARS-CoV-2: Heterogeneity in host defense and therapeutic response

M. A. Schaller, Y. Sharma, Z. Dupee, D. T. Nguyen, J. M. Uruena, R. A. Smolcheck, J. C. Loeb, T. N. Machuca, J. A. Lednicky, D. Odde, R. F. Campbell, W. G. Sawyer, B. Mehrad

This paper develops an in vitro model using cryopreserved human lung tissue to study SARS-CoV-2 infection and drug responses, revealing donor-specific heterogeneity in viral susceptibility and treatment outcomes.

bioRxiv · Jan 20, 2021 · PreprintMicrobiology