N. Khodayari

Correlation of Alpha-1 Antitrypsin Levels and Exosome Associated Neutrophil Elastase Endothelial Injury in Subjects with SARS-CoV2 Infection

The paper investigates the correlation between exosome-associated neutrophil elastase (NE) and alpha-1 antitrypsin levels in SARS-CoV-2 patients, finding that exosome-associated NE is resistant to alpha-1 antitrypsin inhibition and correlates with endothelial injury.

Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency

This study shows that cigarette smoke-exposed airway epithelial cell-derived EVs enhance pro-inflammatory activation of AATD macrophages, increasing cytokine production and neutrophil chemoattractant release.

Neutrophil Elastase Activates Macrophage MMPs, Promotes Cell Adhesion And Cytokine Production Via Integrin-Src Kinases Pathway

This study shows that neutrophil elastase activates macrophages via integrin-Src kinases, increasing MMP activity, cytokine production, and cell adhesion, contributing to tissue destruction in diseases like cystic fibrosis.