Author

J. Lees-Shepard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biochemistry· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. J. Murphy· 1 shared A. N. Economides· 1 shared K. C. Nannuru· 1 shared K. Schutz· 1 shared L. Huang· 1 shared L. Johnsen· 1 shared L. Troncone· 1 shared L. Wang· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. J. Murphy

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1 paper

Recent·Most cited

ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1

S. Aykul, L. Huang, L. Wang, N. Das, S. Reisman, Y. Ray, Q. Zhang, N. Rothman, K. C. Nannuru, V. Kamat, S. Brydges, L. Troncone, L. Johnsen, P. B. Yu, S. Fazio, , S. J. Hatsell

This study shows that ACVR1 antibodies, intended to block ACVR1 activation, instead stimulate heterotopic ossification in FOP by activating FOP-mutant ACVR1 through dimerization.

bioRxiv · Jul 18, 2021Biochemistry