Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 Mutations
Z. You, A. Cheruiyot, S. Li, S. N. Srivatsan, T. Ahmed, Y. Chen, D. S. Lemacon, Y. Li, Z. Yang, B. A. Wadugu, W. Warner, S. M. Pruett-Miller, E. A. Obeng, D. C. Link, D. He, , M. J. Walter
This study identifies NMD as a vulnerability in cancer cells with SF3B1 and U2AF1 mutations, showing increased sensitivity to NMD inhibition and potential therapeutic targeting.
bioRxiv · Mar 19, 2021Cell Biology