Author

B. A. Wadugu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

M. J. Walter· 2 shared S. N. Srivatsan· 2 shared T. Ahmed· 2 shared A. Cheruiyot· 1 shared A. Heard· 1 shared A. Khanna· 1 shared C. A. Miller· 1 shared C. L. Shirai· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

M. J. Walter

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Author profile →

2 papers

Recent·Most cited

U2AF1 is a haplo-essential gene required for cancer cell survival

B. A. Wadugu, A. Heard, S. N. Srivatsan, M. O. Alberti, M. Ndonwi, J. Bradley, J. Shao, T. Ahmed, C. L. Shirai, A. Khanna, D. L. Fei, C. A. Miller, T. A. Graubert, M. J. Walter

This study shows that U2AF1 is a haplo-essential gene for cancer cell survival, as mutant cells depend on residual wild-type U2AF1 for viability and are sensitive to its reduction.

Journal of Clinical Investigation · Nov 1, 2021Peer-reviewedCancer Biology

Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 Mutations

Z. You, A. Cheruiyot, S. Li, S. N. Srivatsan, T. Ahmed, Y. Chen, D. S. Lemacon, Y. Li, Z. Yang, B. A. Wadugu, W. Warner, S. M. Pruett-Miller, E. A. Obeng, D. C. Link, D. He, , M. J. Walter

This study identifies NMD as a vulnerability in cancer cells with SF3B1 and U2AF1 mutations, showing increased sensitivity to NMD inhibition and potential therapeutic targeting.

bioRxiv · Mar 19, 2021Cell Biology