S. M. Pruett-Miller

This study shows that beta 6 integrin suppresses TLR7-mediated epithelial immunity during influenza A virus infection by promoting autophagy and altering TLR7 trafficking.

This study genetically modifies human pluripotent stem cells to evade immune rejection in mice by knocking out HLA genes and adding inhibitory factors, leading to persistent teratomas in immunocompetent models.

This study shows JMJD6 links pre-mRNA splicing and metabolism in MYC-driven cancers, and its inhibition enhances therapeutic response to splicing inhibitors.

The paper uses CRISPR knockout screens to identify drug combinations that enhance the effectiveness of common chemotherapeutics in neuroblastoma cells.

This study compares NGS-based STR profiling with traditional STR-CE for cell line authentication, finding NGS offers better sequence context, sensitivity, and multiplexing.

This study identifies RRM2 and RRM2B as key players in hepatoblastoma progression and drug response, showing their dynamic switching and impact on relapse.

The paper identifies mutual antagonism between glucocorticoid and canonical Wnt signaling pathways in B-cell acute lymphoblastic leukemia, linking TLE1 cis-regulatory disruptions to GC resistance.

This study identifies NMD as a vulnerability in cancer cells with SF3B1 and U2AF1 mutations, showing increased sensitivity to NMD inhibition and potential therapeutic targeting.

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

This study investigates SLFN11's role in pediatric sarcomas, finding it promotes tumor growth and resistance to DNA-damaging agents, which can be overcome by BCL-XL inhibition.

This study identifies the MEKK3-MEK5-ERK5 pathway as a positive regulator of basal mitochondrial degradation independent of exogenous stressors.

The paper identifies the heme-sensing pathway as a regulator of MCL-1 expression in B-lineage acute leukemia, showing that modulating this pathway enhances sensitivity to BH3-mimetics.

This study identifies the Z2 domain of ZBP1 as critical for influenza-induced PANoptosis and perinatal lethality in mice.

This study shows that MAGE-B2 enhances stress tolerance by reducing G3BP and suppressing stress granules, protecting male germline cells from heat stress.