Author

M. J. Walter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. A. Wadugu· 2 shared D. C. Link· 2 shared S. N. Srivatsan· 2 shared T. A. Graubert· 2 shared T. Ahmed· 2 shared A. Cheruiyot· 1 shared A. Heard· 1 shared A. J. Frontier· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

B. A. Wadugu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

U2AF1 is a haplo-essential gene required for cancer cell survival

B. A. Wadugu, A. Heard, S. N. Srivatsan, M. O. Alberti, M. Ndonwi, J. Bradley, J. Shao, T. Ahmed, C. L. Shirai, A. Khanna, D. L. Fei, C. A. Miller, T. A. Graubert, M. J. Walter

This study shows that U2AF1 is a haplo-essential gene for cancer cell survival, as mutant cells depend on residual wild-type U2AF1 for viability and are sensitive to its reduction.

Journal of Clinical Investigation · Nov 1, 2021Peer-reviewedCancer Biology

Immunosuppression and Outcomes in Acute Myeloid Leukemia

F. Ferraro, C. Miller, K. Christensen, N. M. Helton, M. O'Laughlin, C. C. Fronick, R. S. Fulton, J. Kohlschmidt, A.-K. Eisfeld, C. D. Bloomfield, S. M. Ramakrishnan, R. B. Day, L. D. Wartman, G. L. Uy, J. S. Welch, , T. J. Ley

This study identifies immunosuppressive features in AML cells associated with poor outcomes in patients treated with standard chemotherapy.

bioRxiv · Sep 3, 2021 · PreprintCancer Biology

Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 Mutations

Z. You, A. Cheruiyot, S. Li, S. N. Srivatsan, T. Ahmed, Y. Chen, D. S. Lemacon, Y. Li, Z. Yang, B. A. Wadugu, W. Warner, S. M. Pruett-Miller, E. A. Obeng, D. C. Link, D. He, , M. J. Walter

This study identifies NMD as a vulnerability in cancer cells with SF3B1 and U2AF1 mutations, showing increased sensitivity to NMD inhibition and potential therapeutic targeting.

bioRxiv · Mar 19, 2021Cell Biology

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

R. Chatrikhi, C. F. Feeney, M. J. Pulvino, G. Alachouzos, A. J. MacRae, Z. Falls, S. Rai, W. W. Brennessel, J. L. Jenkins, M. J. Walter, T. A. Graubert, R. Samudrala, M. S. Jurica, A. J. Frontier, C. L. Kielkopf

The paper identifies a small molecule that inhibits pre-mRNA splicing by stabilizing an early-stage U2AF2-RNA complex, offering a new strategy for targeting spliceosome assembly.

bioRxiv · Sep 28, 2020Biochemistry