Author

J. M. Bruning

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Biophysics· 1

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:zebrafish· 1

Frequent Co-Authors

B. Tian· 1 shared F. Oltrabella· 1 shared H. Liu· 1 shared J. M. Holton· 1 shared M. P. Jacobson· 1 shared P. Bhattacharya· 1 shared P. M. England· 1 shared R. J. Fletterick· 1 shared

Activity by Year

2018-2018 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

B. Tian

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1 paper

Recent·Most cited

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

J. M. Bruning, Y. Wang, F. Oltrabella, B. Tian, S. A. Kholodar, H. Liu, P. Bhattacharya, S. Guo, J. M. Holton, R. J. Fletterick, M. P. Jacobson, P. M. England

The paper identifies 5,6-dihydroxyindole (DHI) as a dopamine metabolite that covalently modifies and activates Nurr1, a nuclear receptor critical for dopaminergic neuron function, offering potential therapeutic strategies for Parkinson's disease.

bioRxiv · Nov 7, 2018Biophysics