Author

R. J. Fletterick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1 Organism:zebrafish· 1

Frequent Co-Authors

B. Tian· 1 shared D. D. Moore· 1 shared F. Oltrabella· 1 shared H. A. Ingraham· 1 shared H. Liu· 1 shared H. S. Escusa· 1 shared H. Wang· 1 shared J. M. Bruning· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

B. Tian

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Author profile →

2 papers

Recent·Most cited

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

J. M. Bruning, Y. Wang, F. Oltrabella, B. Tian, S. A. Kholodar, H. Liu, P. Bhattacharya, S. Guo, J. M. Holton, R. J. Fletterick, M. P. Jacobson, P. M. England

The paper identifies 5,6-dihydroxyindole (DHI) as a dopamine metabolite that covalently modifies and activates Nurr1, a nuclear receptor critical for dopaminergic neuron function, offering potential therapeutic strategies for Parkinson's disease.

bioRxiv · Nov 7, 2018Biophysics

LRH-1 Mitigates Intestinal Inflammatory Disease by Maintaining Epithelial Homeostasis and Cell Survival

J. R. Bayrer, H. Wang, R. Nattiv, M. Suzawa, H. S. Escusa, R. J. Fletterick, O. D. Klein, D. D. Moore, H. A. Ingraham

This study shows that LRH-1 maintains intestinal epithelial homeostasis and cell survival, and its overexpression mitigates inflammatory damage in IBD models.

bioRxiv · May 22, 2018Cell Biology