Author

J. M. Holton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:virus· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:protein structure· 1

Frequent Co-Authors

A. E. Cohen· 2 shared G. J. Correy· 2 shared G. Meigs· 2 shared I. D. Young· 2 shared J. S. Fraser· 2 shared M. C. Thompson· 2 shared S. Gahbauer· 2 shared S. Russi· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

A. E. Cohen

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Author profile →

5 papers

Recent·Most cited

Mapping Protein Dynamics at High-Resolution with Temperature-Jump X-ray Crystallography

A. M. Wolff, E. Nango, I. D. Young, A. S. Brewster, M. Kubo, T. Nomura, M. Sugahara, S. Owada, B. A. Barad, K. Ito, A. Bhowmick, S. Carbajo, T. Hino, J. M. Holton, D. Im, , M. C. Thompson

This study uses temperature-jump X-ray crystallography to observe atomic-scale protein motions in lysozyme, showing how vibrations evolve into functional movements and how inhibitors alter these dynamics.

bioRxiv · Jun 10, 2022Biophysics

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature

G. J. Correy, D. W. Kneller, G. Phillips, S. Pant, S. Russi, A. E. Cohen, G. Meigs, J. M. Holton, S. Gahbauer, M. C. Thompson, A. Ashworth, L. Coates, A. Kovalevsky, F. Meilleur, J. S. Fraser

This study determines the crystal structures of SARS-CoV-2 NSP3 macrodomain using neutron and X-ray diffraction, revealing insights into its catalytic mechanism and ligand binding.

bioRxiv · Feb 7, 2022Biochemistry

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

M. Schuller, G. J. Correy, S. Gahbauer, D. Fearon, T. Wu, R. E. Diaz, I. D. Young, L. Carvalho Martins, D. H. Smith, U. Schulze-Gahmen, T. W. Owens, I. Deshpande, G. E. Merz, A. C. Thwin, J. T. Biel, , Smi

The paper identifies new chemical fragments binding to the SARS-CoV-2 Nsp3 macrodomain through crystallographic screening and computational docking, validating their binding with biophysical techniques.

bioRxiv · Nov 24, 2020Biochemistry

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

J. M. Bruning, Y. Wang, F. Oltrabella, B. Tian, S. A. Kholodar, H. Liu, P. Bhattacharya, S. Guo, J. M. Holton, R. J. Fletterick, M. P. Jacobson, P. M. England

The paper identifies 5,6-dihydroxyindole (DHI) as a dopamine metabolite that covalently modifies and activates Nurr1, a nuclear receptor critical for dopaminergic neuron function, offering potential therapeutic strategies for Parkinson's disease.

bioRxiv · Nov 7, 2018Biophysics

Challenge data set for macromolecular multi-microcrystallography

J. M. Holton

The paper generates a synthetic dataset to benchmark multi-crystal macromolecular crystallography methods under radiation damage and indexing ambiguity.

bioRxiv · Aug 18, 2018Biophysics