Cancer BiologybioRxivPreprint
SAMHD1 promotes oncogene-induced replication stress
S. M. Zhang, J. M. Calderon-Montano, S. G. Rudd
This study identifies SAMHD1 as a tumor suppressor that promotes replication stress in oncogene-driven cells by slowing DNA replication fork speeds and reducing cell proliferation.
DOI 10.1101/2020.07.29.226282