Author

S. G. Rudd

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

S. M. Zhang· 3 shared T. Helleday· 3 shared A. Hagenkort· 2 shared A.-S. Jemth· 2 shared C. E. Strom· 2 shared H. Gad· 2 shared M. Scobie· 2 shared N. Amaral· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

S. M. Zhang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

S. M. Zhang, C. B. Paulin, M. Michel, P. Marttila, M. Yagüe-Capilla, H. C. Bwanika, H. Shu, R. Papagudi Vekatram, E. Wiita, A.-S. Jemth, I. Almlöf, O. Loseva, F. Ortis, C. Dirks, T. Koolmeister, , S. G. Rudd

This paper identifies and evaluates small-molecule inhibitors of SAMHD1 through a comprehensive screening pipeline, revealing a novel mode of inhibition and potential therapeutic applications.

bioRxiv · Jan 17, 2023 · PreprintBiochemistry

Drug synergy scoring using minimal dose response matrices

P. Mäkelä, S. M. Zhang, S. G. Rudd

This paper optimizes drug synergy scoring by determining the minimal dose response matrix size needed to robustly detect and quantify synergy between two drugs.

BMC Research Notes · Jan 19, 2021Peer-reviewedPharmacology & Toxicology

SAMHD1 promotes oncogene-induced replication stress

S. M. Zhang, J. M. Calderon-Montano, S. G. Rudd

This study identifies SAMHD1 as a tumor suppressor that promotes replication stress in oncogene-driven cells by slowing DNA replication fork speeds and reducing cell proliferation.

bioRxiv · Jul 29, 2020 · PreprintCancer Biology

MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression

S. G. Rudd, H. Gad, N. Amaral, A. Hagenkort, P. Groth, C. E. Strom, O. Mortusewicz, U. Warpman-Berglund, T. Helleday

The paper shows that MTH1 inhibitor TH588 causes genomic 8-oxodG accumulation during mitosis, leading to mitotic arrest and cytotoxicity.

bioRxiv · Sep 6, 2019Cancer Biology

MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

H. Gad, O. Mortusewicz, S. G. Rudd, A. Stolz, N. Amaral, L. Brautigam, L. Pudelko, K. Sanjiv, C. Kalderen, A.-S. Jemth, I. Almlof, T. Visnes, N. Schultz, J. Bostrom, J. M. Calderon Montano, , T. Helleday

This study identifies MTH1's role in mitosis and shows that potent MTH1 inhibitors cause mitotic arrest by disrupting tubulin polymerization and suppressing ROS.

bioRxiv · Sep 5, 2019 · PreprintCancer Biology