Mechanism of preferential complex formation by Apoptosis Signal-regulating Kinases
S. J. Trevelyan, J. L. Brewster, A. E. Burgess, J. M. Crowther, A. L. Cadell, B. L. Parker, D. R. Croucher, R. C. Dobson, J. M. Murphy, P. D. Mace
This study identifies the mechanism by which ASK1-3 kinases form preferential heterocomplexes through their SAM domains, revealing structural insights into their role in inflammatory signaling.
bioRxiv · Jul 5, 2019Biochemistry