Author

R. Dobson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

M. Currie· 2 shared R. Friemann· 2 shared A. Gulati· 1 shared A. J. Hodgkinson· 1 shared B. Demeler· 1 shared C. Indiveri· 1 shared C. Tey· 1 shared D. Bjerke· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

M. Currie

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

On the function of TRAP substrate-binding proteins: conformational variation of the sialic acid binding protein SiaP

T.-R. J. King-Hudson, J. S. Davies, S. Quan, M. Currie, Z. D. Tillett, J. Copping, S. Panjikar, R. Friemann, J. R. Allison, R. A. North, R. Dobson

This study solves the structure of the TRAP substrate-binding protein AaSiaP in different conformations, revealing how it binds N-acetylneuraminate and stabilizes a closed state.

bioRxiv · Apr 30, 2024Biochemistry

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

M. Currie, J. Davies, M. Scalise, A. Gulati, J. Wright, M. Newton-Vesty, G. Abeysekera, R. Subramanian, W. Wahlgren, R. Friemann, J. Allison, P. Mace, M. Griffin, B. Demeler, S. Wakatsuki, , R. North

This study reports the cryo-EM structure of a TRAP transporter from Haemophilus influenzae, revealing its dimeric architecture, Na+ sites, and substrate binding site, supported by mutagenic and functional data.

bioRxiv · Aug 28, 2023 · PreprintBiochemistry

The vitamin A ester retinyl propionate has a unique metabolic profile and higher retinoid-related bioactivity over retinol and retinyl palmitate in human skin models.

D. Bjerke, R. Li, J. M. Price, R. Dobson, M. Rodrigues, C. Tey, L. Vires, R. L. Adams, J. D. Sherrill, P. B. Styczynski, K. Goncalves, V. Maltman, S. Przyborski, J. Oblong

This study compares the metabolic profiles and bioactivity of retinol, retinyl palmitate, and retinyl propionate in human skin models, finding RP has higher bioactivity and unique metabolism.

bioRxiv · Sep 26, 2020Biochemistry

Interactions in milk suggest a physiological role for β-lactoglobulin

J. M. Crowther, M. Broadhurst, T. M. Laue, G. B. Jameson, A. J. Hodgkinson, R. Dobson

The paper identifies interactions between β-lactoglobulin and immunoglobulins in ruminant milk, suggesting β-lactoglobulin protects immunoglobulins during digestion to facilitate their transfer from mother to offspring.

bioRxiv · Jun 19, 2019 · PreprintBiophysics