Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
S. Harjes, H. M. Kurup, A. E. Rieffer, M. Bayarjagal, J. Filitcheva, Y. Su, T. K. Hale, V. V. Filichev, E. Harjes, R. S. Harris, G. B. Jameson
This paper identifies a structural basis for inhibiting APOBEC3A, a mutagenic enzyme in cancer, using a hairpin DNA inhibitor that blocks its activity in human cells.
bioRxiv · Feb 17, 2023Cancer Biology