Vaccine Hyporesponse Induced By Individual Antibiotic Treatment In Mice And Non-Human Primates Is Diminished Upon Recovery Of The Gut Microbiome
G. Swaminathan, M. Citron, J. Xiao, J. E. Norton, A. L. Reens, B. D. Topcuoglu, J. M. Maritz, K.-J. Lee, D. Freed, T. M. Weber, C. H. White, M. Kadam, E. Spofford, E. Bryant-Hall, G. Salituro, , G. D. Hannigan
This study shows that antibiotic-induced gut microbiome disruption reduces vaccine response in mice and non-human primates, but recovery of microbiome diversity restores immune responses.
bioRxiv · Apr 2, 2021Immunology