Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations
A. Grieco, S. Boneta, J. A. Gavira, A. L. Pey, S. Basu, J. Orlans, D. de Sanctis, M. Medina, J. M. Martin Garcia
This study determines the structure of hNQO1 with NADH using serial crystallography and simulations, showing NADH binding stabilizes the protein and drives functional cooperativity through structural communication.
Protein Science · Mar 19, 2024Peer-reviewedBiochemistry