Author

D. de Sanctis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Approach:biophysical modeling· 2 Research Focus:cell type annotation· 2 Organism:Arabidopsis· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. Orlans· 2 shared L. Jovine· 2 shared S. Basu· 2 shared S. Nishio· 2 shared A. E. Carlson· 1 shared A. Grieco· 1 shared A. L. Pey· 1 shared A. M. Orville· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

J. Orlans

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations

A. Grieco, S. Boneta, J. A. Gavira, A. L. Pey, S. Basu, J. Orlans, D. de Sanctis, M. Medina, J. M. Martin Garcia

This study determines the structure of hNQO1 with NADH using serial crystallography and simulations, showing NADH binding stabilizes the protein and drives functional cooperativity through structural communication.

Protein Science · Mar 19, 2024Peer-reviewedBiochemistry

Metal ion activation and DNA recognition by the Deinococcus radiodurans manganese sensor DR2539

C. Mota, M. Webster, M. Saidi, U. Kapp, C. Zubieta, G. Giachin, J. A. Manso, D. de Sanctis

This study investigates the metal ion activation and DNA recognition mechanisms of DR2539 in Deinococcus radiodurans using biophysical analyses and structural data.

bioRxiv · Feb 12, 2024 · PreprintBiophysics

Droplet microfluidics for time-resolved serial crystallography

J. Stubbs, T. Hornsey, N. Hanrahan, L. Blay-Esteban, R. Bolton, M. Maly, S. Basu, J. Orlans, D. de Sanctis, J.-u. Shim, P. D. Shaw Stewart, A. M. Orville, I. Tews, J. West

This paper develops a droplet microfluidics approach to produce uniform crystals and enable rapid micromixing for time-resolved serial crystallography.

bioRxiv · Jan 12, 2024Biochemistry

Architecture of the Vertebrate Egg Coat and Structural Basis of the ZP2 Block to Polyspermy

S. Nishio, C. Emori, B. Wiseman, D. Fahrenkamp, E. Dioguardi, S. Zamora-Caballero, M. Bokhove, L. Han, A. Stsiapanava, Y. Lu, M. Kodani, R. E. Bainbridge, K. M. Komondor, A. E. Carlson, M. Landreh, , L. Jovine

This study investigates how cleavage of ZP2 in the egg zona pellucida leads to oligomerization and structural changes that block polyspermy.

bioRxiv · Jun 21, 2023Biophysics

Discovery of archaeal Fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins

D. Moi, S. Nishio, X. Li, C. Valansi, M. Langleib, N. G. Brukman, K. Flyak, C. Dessimoz, D. de Sanctis, K. Tunyasuvunakool, J. Jumper, M. Grana, H. Romero, P. S. Aguilar, L. Jovine, B. Podbilewicz

The paper identifies archaeal proteins homologous to eukaryotic gamete fusion proteins and shows they can mediate cell fusion.

bioRxiv · Oct 13, 2021Evolutionary Biology